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This is a In Vitro Study study (also classified as: Animal Study).

August 19, 2025Frontiers in ImmunologyOpen Access

NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release

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Research demonstrates NINJ1's role in apoptotic body formation and content release, suggesting new mechanisms for inflammation regulation.

NINJ1 regulates the release of inflammatory signals linked to apoptotic bodies and norovirus particles, indicating its critical role in cell disassembly.
Higher-order NINJ1 oligomerisation occurs on apoptotic bodies, impacting their stability and cellular content release.
Apoptotic bodies facilitate dead cell clearance, highlighting the importance of NINJ1 in the process of apoptosis and inflammation.
The research enhances understanding of the mechanisms behind plasma membrane rupture during apoptosis, with implications for inflammatory responses.

Shi et al. (2025) studied this question.

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Research demonstrates NINJ1's role in apoptotic body formation and content release, suggesting new mechanisms for inflammation regulation.