What does this research mean for the field?

NINJ1 mediates plasma membrane rupture in regulated cell death and plays a dual, context-dependent role in cancer, acting as both a tumor suppressor via immunogenic cell death and a tumor promoter via chronic inflammation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To elucidate the molecular structure, oligomerization mechanisms, and functional roles of NINJ1 in regulated cell death pathways and tumor progression.

September 14, 2026Journal of Cancer Research and Clinical OncologyOpen Access

NINJ1 in regulated cell death and cancer: a plasma membrane rupture executor with dual roles in tumor progression

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Authors

JZJiankang ZhouSoochow University MLMin LiCentral South University STSipin TanCentral South University

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Implication

Systematic review reveals opposing roles of NINJ1 in tumor progression, highlighting its function as a cell membrane rupture executor across regulated cell death pathways.

Key Points

To elucidate the molecular structure, oligomerization mechanisms, and functional roles of NINJ1 in regulated cell death pathways and tumor progression.
Conducted a systematic literature review analyzing NINJ1 across various regulated cell death pathways, tumor biology, and immune modulation contexts.
NINJ1 executes plasma membrane rupture across multiple regulated cell death types—including pyroptosis, necroptosis, ferroptosis, secondary necrosis, and PANoptosis—mediating intracellular content release and shaping inflammatory responses.
The protein displays dual, context-dependent roles in cancer by either suppressing tumors through immunogenic cell death or promoting tumor growth, metastasis, and immunosuppression via chronic inflammation and pathways like the p53–NINJ1–xCT axis.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3aa0926e14a848b2c65 https://doi.org/10.1007/s00432-026-06592-9

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Implication

Systematic review reveals opposing roles of NINJ1 in tumor progression, highlighting its function as a cell membrane rupture executor across regulated cell death pathways.

NINJ1 in regulated cell death and cancer: a plasma membrane rupture executor with dual roles in tumor progression

Discussion

Member takes

Implication

Key Points

Cite This Study

NINJ1 in regulated cell death and cancer: a plasma membrane rupture executor with dual roles in tumor progression

Discussion

Member takes

Implication

Key Points

Cite This Study

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