Figure 3 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Oncogenic mutations defining a concurrent mutation signature in bowel polyps. A, Venn diagram to show the selection criterion of polyps with concurrent mutations in two of three molecular pathways. B, Oncogenic mutations in low-grade polyps with concurrent mutations. C, Oncogenic mutations in low-grade polyps without concurrent mutations. D, Box plot of MB between polyp groups, colorectal cancer CRC, and normal mucosa (top and bottom quartiles and mean are shown; the top whisker is the maximum value plus 1.5 × IQR, and the bottom whisker is the minimum value minus 1.5 × IQR). TMB, tumor MB; ns, not significant.