Figure 4 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Volcano plots showing differentially expressed genes between different polyp histologic segments. A, Epithelial segments (PanCK+) of polyps with concurrent mutations epithelial segments vs. polyps without concurrent mutations. B, Immune segments (CD45⁺) of polyps with concurrent mutations vs. polyps without concurrent mutations. An adjusted P value of 0.05 (−log₁₀P value of 1.3; GLM likelihood ratio test; Benjamini–Hochberg method FDR <0.05) and log₂ FC of 0.5 were used as cutoffs. Red denotes genes increased in relative expression, blue denotes genes decreased in relative expression, and gray denotes genes that did not exceed differential expression thresholds.