June 1, 2025

[Clinical study on the effect of glycosaminoglycans on vascular endothelial glycocalyx in sepsis].

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Discussion

Prospective study shows GAG reduces inflammatory markers and vascular glycocalyx degradation in sepsis patients, suggesting improved prognosis.

The GAG intervention significantly lowered vascular endothelial glycocalyx degradation markers compared to conventional treatment.
Glycosaminoglycans reduced inflammation and improved severity scores in sepsis patients after 7 days of treatment.
Analysis indicated both HS and CRP are strong predictors of prognosis for sepsis patients, emphasizing their clinical importance.
GAG therapy led to shorter hospital stays without significantly affecting mortality rates compared to the conventional group.

Tang et al. (2025) studied this question.

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Prospective study shows GAG reduces inflammatory markers and vascular glycocalyx degradation in sepsis patients, suggesting improved prognosis.