What type of study is this?

This is a Case-Control Study study.

October 11, 2025Critical Care ExplorationsOpen Access

Biomarkers of Microcirculatory Dysfunction in Sepsis: A Pilot Prospective Observational Study

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Observational study compares sublingual microscopy and LC-MS/MS in sepsis patients, suggesting new biomarker utility.

LC-MS/MS showed the highest diagnostic performance for identifying sepsis with an AUC of 0.85, surpassing other methods.
Sublingual microvascular parameters were significantly correlated with urinary glycosaminoglycan levels, reinforcing their biological relevance.
Prospective, observational case-control study included 44 sepsis patients and 24 healthy controls for comparison.
Findings suggest LC-MS/MS quantification of glycosaminoglycans could enhance effective sepsis patient management strategies.

Longino et al. (2025) studied this question.

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