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August 15, 2025American Journal of Health-System Pharmacy

Establishing a CYP3A5 genotype–guided tacrolimus dosing protocol in adult kidney transplant recipients

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Authors

APAmy L. PasternakUniversity of MichiganCZChristopher ZimmermanOregon Health & Science UniversityJPJeong Mi ParkUniversity of Michigan

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Overview

Implementation of a genotype-guided tacrolimus dosing protocol improves outcomes in adult kidney transplant recipients, suggesting tailored pharmacotherapy approaches.

Key Points

  • Implementation of a CYP3A5 genotype-guided dosing protocol led to 61% of adult kidney transplant recipients receiving personalized tacrolimus doses.
  • Genotype-guided dosing was launched in October 2023 after developing workflows for patient testing and education.
  • The approach involved collaboration among multidisciplinary teams to enhance the integration of pharmacogenetics into clinical practice.
  • Future evaluations will assess the impact of genotype-guided dosing on clinical outcomes and healthcare utilization.

Cite This Study

Pasternak et al. (2025) studied this question.

synapsesocial.com/papers/68af4754ad7bf08b1ead3ceehttps://doi.org/10.1093/ajhp/zxaf215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimization of Initial Tacrolimus Dose Using Pharmacogenetic Testing2010 · 366 citations
  2. 2OPTN/SRTR 2022 Annual Data Report: Kidney2024 · 208 citations
  3. 3Establishment of a Pharmacogenetics Service Focused on Optimizing Existing Pharmacogenetic Testing at a Large Academic Health Center2020 · 20 citations
  4. 4Impact of CYP3A5 phenotype on tacrolimus time in therapeutic range and clinical outcomes in pediatric renal and heart transplant recipients2021 · 14 citations
  5. 5Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and CYP3A5 genotype‐guided doses in renal transplantation patients2019 · 31 citations