Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 26, 2025GenesOpen Access

Pharmacogenetics Approach for Personalized Tacrolimus Dosing in Heart Transplantation: A Case Report and Literature Review

View Full Paper
Ask AI
Bookmark
Share

Authors

NNNives NikpaljJSJure SamardžićNBNada Božina

Discussion

Loading...

Member takes

Overview

Case report demonstrates enhanced tacrolimus efficacy via pharmacogenetic insights in heart transplant patients, suggesting broader applications.

Key Points

  • Achieving therapeutic tacrolimus levels improved clinical outcomes for a heart transplant recipient on pharmacogenetic guidance.
  • Initial dosing was 3.5 mg twice daily, increased to 7.0 mg, and stabilized at 6.5 mg, achieving therapeutic targets after pharmacogenetic adjustment.
  • Pharmacogenetic analysis revealed CYP3A5 expresser genotype, prompting dosing modification alongside a CYP3A4 inhibitor.
  • Genotype-guided dosing holds potential for optimizing immunosuppressive therapies, yet routine implementation remains limited.

Cite This Study

Nikpalj et al. (2025) studied this question.

synapsesocial.com/papers/68af63ddad7bf08b1eae3f0chttps://doi.org/10.3390/genes16091010
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Establishing a <i>CYP3A5</i> genotype–guided tacrolimus dosing protocol in adult kidney transplant recipients2025
  2. 2B-222 Receptor-donor CYP3A5 and CYP3A4 genotype testing in liver transplant patients and its influence in tacrolimus blood levels: a retrospective study2024
  3. 3Cohort Study to Determine the Impact of <i>CYP3A5</i> Genotype on Tacrolimus Dosing Requirements and Trough Concentrations in Heart Transplant Recipients2026
  4. 4Influence of Genetic Polymorphisms in CYP3A5, CYP3A4, and MDR1 on Tacrolimus Metabolism after kidney transplantation2024 · 6 citations
  5. 5Pattern of CYP3A5 and MDR-1 single nucleotide polymorphism and its impact on Tacrolimus levels and clinical outcomes in living renal allograft recipient2024