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This is a In Vitro Study study.

August 17, 2025Scientific ReportsOpen Access

A 2D inflammatory co-culture model for investigating synovial fibroblast and macrophage interactions in rheumatoid arthritis

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Direct exposure of fibroblast-like synoviocytes to inflammatory macrophages significantly increased pro-inflammatory cytokines.
The model showed elevated matrix metalloproteinases, with MMP9 expression rising by 37.61-fold, indicating joint degradation.
Utilizing a transwell system, the co-culture facilitated indirect macrophage exposure, enhancing fibroblast invasion and reflecting chronic inflammation.
Therapeutic testing with methotrexate revealed its anti-invasive effect on activated fibroblasts, highlighting the model's potential for drug screening.

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Co-culture model reveals macrophage-induced inflammation in fibroblasts, suggesting new avenues for RA therapy.

Thangadurai et al. (2025) studied this question.

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