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This is a Experimental Study study.

September 24, 2025Advanced ScienceOpen Access

Synovium‐On‐A‐Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast‐Like Synoviocytes

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The synovium-on-a-chip model recapitulates key features of rheumatoid arthritis inflammation over 9 days.
The study finds that a 1:1:1 coculture ratio of cells maintains elevated inflammatory cytokines IL-6 and IL-8.
Using microfluidic chips and 3D cultures, the study developed a vascularized immune-activated model for research.
This model may enhance the prediction of drug responses in rheumatoid arthritis, aiding preclinical assessments.

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This plastic model mimics inflammatory responses in rheumatoid arthritis tissues, suggesting effective drug testing applications.

Diao et al. (2025) studied this question.

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