Solitary Neurofibroma in Lower Lip — A Case Report

The WHO Classification of Head and Neck Tumors (2024) defines solitary neurofibromas as benign peripheral nerve sheath tumors comprising a mixture of Schwann cells, perineuronal cells, fibroblasts, and axons. In the orofacial region, such tumors usually occur on the tongue, and only rarely in the lip. This report describes a case of a solitary neurofibroma arising in the lower lip. The patient was a 59-year-old man who was referred to our hospital with a mass on the lower lip. Palpation revealed that it was elastic, hard, painless, and mobile. Magnetic resonance imaging confirmed the presence of a mass. It was identified as a suspected benign tumor and surgical excision conducted under general anesthesia. A diagnosis of solitary neurofibroma was made based on histopathological findings. One and a half years have passed since the surgery, and no recurrence has been noted. Long-term follow-up has been planned.