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August 17, 2025BioData MiningOpen Access

Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses

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Authors

YYYu YinAnhui Medical UniversityCZChenkai ZhaoZhejiang Chinese Medical UniversityYHYibo HuaNanjing Medical University

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Overview

Genome-wide association study uncovers shared genetic risk loci in chronic kidney disease and metabolic syndrome, suggesting new treatment avenues.

Key Points

  • Shared genetic mechanisms were found linking chronic kidney disease and metabolic syndrome-related diseases, highlighting the importance of pleiotropy.
  • Cross-trait pleiotropy analysis identified 1,437 significant pleiotropic loci and confirmed 44 risk SNP loci associated with these conditions.
  • Functional annotations revealed connections between key tissues like the brain and adipose tissue in their shared genetic pathways.
  • Mendelian randomization analysis indicated a metabolic intermediary mechanism that relates chronic kidney disease to metabolic syndrome.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68af4754ad7bf08b1ead3d97https://doi.org/10.1186/s13040-025-00472-7
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