What does this research mean for the field?

Cardiovascular-kidney-metabolic (CKM) syndrome has a distinct genetic architecture characterized by 260 novel SNPs, 92 causal SNPs, and 10 susceptible genes that are primarily enriched in metabolic cells and pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To resolve the genetic architecture, causal genetic variants, and tissue-specific biological pathways underlying cardiovascular-kidney-metabolic syndrome.

September 8, 2026Scientific ReportsOpen Access

Integrative genomic dissection of cardio-kidney-metabolic syndrome reveals novel loci, causal genes, and tissue-specific pathways in European populations

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Authors

ZWZhonghai Wang XCXin Chen HWHan Wang

Discussion

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Overview

Multivariate genome-wide association study uncovers novel loci and causal genes for cardio-kidney-metabolic syndrome in Europeans, highlighting shared pathways for precision medicine.

Key Points

To resolve the genetic architecture, causal genetic variants, and tissue-specific biological pathways underlying cardiovascular-kidney-metabolic syndrome.
Conducted a multivariate genome-wide association study (mvCKM) in European populations using genomic structural equation modelling.
Performed post-GWAS evaluations including transcriptome-wide association analysis, cellular pathway enrichment, partitioned heritability, and polygenic risk score calculations across chromosomes.
Identified 260 novel single-nucleotide polymorphisms (SNPs), estimated 92 causal SNPs independent of single phenotypes, and pinpointed 10 susceptibility genes.
Observed significant mvCKM enrichment in metabolic cells, tissues, and conserved genomic regions, with major polygenic risk score contributions localized to chromosomes 4, 6, 1, and 9.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd78a58e84d0ff5b463aa https://doi.org/10.1038/s41598-026-65774-0

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September 8, 2026Scientific ReportsOpen Access

Integrative genomic dissection of cardio-kidney-metabolic syndrome reveals novel loci, causal genes, and tissue-specific pathways in European populations

View Full Paper

Ask AI

Bookmark

Authors

ZWZhonghai Wang XCXin Chen HWHan Wang

Discussion

Member takes

Overview

Multivariate genome-wide association study uncovers novel loci and causal genes for cardio-kidney-metabolic syndrome in Europeans, highlighting shared pathways for precision medicine.

Key Points

To resolve the genetic architecture, causal genetic variants, and tissue-specific biological pathways underlying cardiovascular-kidney-metabolic syndrome.
Conducted a multivariate genome-wide association study (mvCKM) in European populations using genomic structural equation modelling.
Performed post-GWAS evaluations including transcriptome-wide association analysis, cellular pathway enrichment, partitioned heritability, and polygenic risk score calculations across chromosomes.
Identified 260 novel single-nucleotide polymorphisms (SNPs), estimated 92 causal SNPs independent of single phenotypes, and pinpointed 10 susceptibility genes.
Observed significant mvCKM enrichment in metabolic cells, tissues, and conserved genomic regions, with major polygenic risk score contributions localized to chromosomes 4, 6, 1, and 9.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd78a58e84d0ff5b463aa https://doi.org/10.1038/s41598-026-65774-0

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