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September 18, 2025Open Access

Cardio-Kidney-Metabolic Syndrome: Candidate Subtypes and Genetic Risk Factors

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Authors

HDHylke C. DonkerVBVandana BishtODOm Prakash Dwivedi

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Overview

Analysis reveals five candidate subtypes and 57 genetic variants linked to cardiovascular-kidney-metabolic syndrome.

Key Points

  • Five candidate subtypes were identified, each presenting varying biomarker profiles and health outcomes.
  • Analysis of 121,918 participants led to the discovery of five subtypes tied to kidney disease and diabetes.
  • Genome-wide association studies identified 57 significant genetic variants specific to each CKM subtype.
  • Distinct genetic architectures were observed, enhancing understanding of disease variability and detection.

Cite This Study

Donker et al. (2025) studied this question.

synapsesocial.com/papers/68d463db31b076d99fa62ca4https://doi.org/10.21203/rs.3.rs-7602643/v1
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