Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 22, 2025

Metabolomic Profiling Reveals Interindividual Metabolic Variability and Its Association with Cardiovascular-Kidney-Metabolic Disease Risk

View Full Paper
Ask AI
Bookmark
Share

Authors

MZMeng ZhouWSWenxiu SunYGYuhan Gao

Discussion

Loading...

Member takes

Overview

Cross-sectional study identifies metabolic clusters in 163 adults, suggesting tailored management strategies for high-risk cardiovascular-kidney-metabolic individuals.

Key Points

  • Distinct metabolic clusters related to cardiovascular-kidney-metabolic disease were identified through untargeted metabolomic profiling.
  • High-risk individuals primarily fell into a metabolic cluster characterized by elevated triglycerides and fatty acids (p < 0.001).
  • A total of 390 metabolites were analyzed, revealing significant metabolic heterogeneity among different CKM stages.
  • A panel of 20 metabolites displayed high diagnostic performance for identifying stage 3 CKM individuals with an AUC of 0.875.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd82ahttps://doi.org/10.21203/rs.3.rs-6870432/v1
View Full Paper
Ask AI
Bookmark
Share