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August 19, 2025

Peripheral Blood Mononuclear Cell Gene Expression Signatures Predict Long-term Survivorship in Canine DLBCL

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Authors

KRKirthana RaoUniversity of Massachusetts Chan Medical SchoolZRZechuan RaoUniversity of Massachusetts Chan Medical SchoolAHAi HuangUniversity of Massachusetts Chan Medical School

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Implication

Clinical trial demonstrates gene expression profiles in PBMCs predict relapse in dogs with DLBCL, suggesting immune signatures influence outcomes.

Key Points

  • Increased expression of immune skewing genes correlates with shorter survival times in dogs with DLBCL, indicating potential biomarkers for early relapse.
  • Long-term survivors show elevated levels of specific genes post-immunotherapy, suggesting they may indicate protective immune responses against DLBCL.
  • Analysis utilized the NanoString Canine IO panel to track changes in gene expression in PBMCs of dogs undergoing treatment.
  • qPCR assays for key biomarkers could facilitate early identification of dogs at risk of relapse, enhancing management strategies.

Cite This Study

Rao et al. (2025) studied this question.

synapsesocial.com/papers/68af4754ad7bf08b1ead3fc4https://doi.org/10.21203/rs.3.rs-7110482/v1
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