Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Longitudinal single-cell profiling in canine DLBCL reveals regulatory networks driving chemotherapy resistance.

View Full Paper
Ask AI
Bookmark
Share

Authors

MBMarjorie BrandXPXuan Pan

Discussion

Loading...

Member takes

Overview

Longitudinal analysis identifies key regulatory networks in dogs with DLBCL, suggesting new therapy targets.

Key Points

  • Investigate the biological mechanisms driving chemotherapy resistance in canine DLBCL using single-cell profiling.
  • Conducted longitudinal sampling of tumor biopsies from dogs at diagnosis, remission, and relapse.
  • Performed single cell RNA sequencing on hundreds of thousands of cells from lymph node biopsies.
  • Applied machine learning tools for batch correction and regulatory network inference.
  • Identified a persistent B cell population associated with therapy resistance across disease stages.
  • Mapped regulatory networks implicating transcription factors relevant to chemotherapy resistance.
  • Highlighted Wnt and Akt signaling pathways as active in the resistant clones.

Cite This Study

Brand et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d770https://doi.org/10.1182/blood-2025-1788
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune profiling of canine B cell lymphoma reveals cross-species conservation of prognostic markers2025 · 2 citations
  2. 2Peripheral Blood Mononuclear Cell Gene Expression Signatures Predict Long-term Survivorship in Canine DLBCL2025
  3. 3Peripheral blood mononuclear cell gene expression signatures predict long-term survivorship in canine DLBCL2026
  4. 4Abstract A020: Characterizing the disease pathogenesis and translational potential of naturally occurring canine small cell B cell lymphoma2026
  5. 5Abstract A023: Different paths to the same destination: Molecular divergence and functional convergence in human and canine lymphomas2026