Pregnancy-Induced Thrombotic Thrombocytopenic Purpura Complicated by Atypical Posterior Reversible Encephalopathy Syndrome and Acute Pancreatitis: A Rare Presentation

Pregnancy is a documented trigger for thrombotic thrombocytopenic purpura (TTP), a rapidly progressing condition that is often misdiagnosed as HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. Here, we present the case of a 28-year-old pregnant female, gravida 2 para 1, who was admitted for complaints of seizures, vomiting, fever, decreased perception of fetal movements, and visual impairment. She was found to have posterior reversible encephalopathy syndrome, acute kidney injury, and acute pancreatitis, along with her diagnosis of TTP. She improved with plasma exchange and recovered well. Maternal and fetal survival in TTP patients depends heavily on early diagnosis, swift initiation of therapeutic plasma exchange, and vigilant monitoring throughout pregnancy and the postpartum period. This case emphasizes the importance of ruling out differentials often grouped with TTP in resource-limited settings.