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August 19, 2025Communications BiologyOpen Access

Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryos

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Authors

ASAnala V. ShettyUniversity of MinnesotaCSClifford J. SteerUniversity of MinnesotaWLWalter C. LowUniversity of Minnesota

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Implication

Single-cell analysis reveals replication timing links with gene expression in early mouse embryos, suggesting novel developmental insights.

Key Points

  • Replication timing is established as early as the 1-cell stage, indicating a crucial developmental period.
  • We detect a correlation where late replicating regions associate with increased gene expression during early development.
  • Our method employs a single-cell multiomics approach to explore gene expression alongside replication timing.
  • Higher gene expression in late replicating regions suggests distinct control mechanisms in early totipotent embryos compared to somatic cells.

Cite This Study

Shetty et al. (2025) studied this question.

synapsesocial.com/papers/68af475aad7bf08b1ead415dhttps://doi.org/10.1038/s42003-025-08694-5
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