August 12, 2025Journal of Biological ChemistryOpen Access

A Single Cell Multiomics Approach for Simultaneous Analysis of Replication Timing and Gene Expression

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Authors

ASAnala V. ShettyUniversity of Minnesota CSClifford J. SteerUniversity of Minnesota WLWalter C. LowUniversity of Minnesota

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Implication

Novel single cell approach reveals correlation between replication timing and gene expression in HepG2 cells, showing new insights for cancer research.

Key Points

Replication timing analysis can reveal gene expression patterns in cells during the S-phase of the cell cycle, highlighting important cellular processes.
Using only 17 mid S-phase cells, cell-type specific pseudo bulk replication timing profiles were produced, correlating highly with existing bulk data.
This innovative single cell multiomics approach allows detailed visualization of genome replication across individual cells in cancer research.
Findings indicate that both conserved and variable trends in replication timing and gene expression at the single cell level have not been observed in bulk studies.

Cite This Study

Shetty et al. (2025) studied this question.

synapsesocial.com/papers/68a3633d0a429f7973329d55 https://doi.org/10.1016/j.jbc.2025.110581

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Implication

Novel single cell approach reveals correlation between replication timing and gene expression in HepG2 cells, showing new insights for cancer research.

A Single Cell Multiomics Approach for Simultaneous Analysis of Replication Timing and Gene Expression

Discussion

Member takes

Implication

Key Points

Cite This Study

A Single Cell Multiomics Approach for Simultaneous Analysis of Replication Timing and Gene Expression

Discussion

Member takes

Implication

Key Points

Cite This Study

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