March 22, 2024Cancer Research

Single-Cell DNA Replication Timing and Clonal Dynamics in Genomically Unstable Cancers

View Full Paper

Ask AI

Bookmark

DNA replication timing profiles correlate with future somatic copy number alterations, while cell lineage serves as the primary determinant of replication heterogeneity.
Across 50,000 single cells, whole genome doubling promoted late S-phase accumulation and reduced overall proliferation rates across breast and ovarian cancer models.
Assessment using a Bayesian framework resolved single-cell whole genome sequencing profiles, though xenograft models require further validation in clinical cohorts.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Preclinical genomic analysis reveals clone-specific DNA replication timing in breast and ovarian cancers, highlighting how copy number alterations alter subclone fitness.

Cite This Study

Weiner et al. (2024) studied this question.

synapsesocial.com/papers/68e72e3db6db6435876a8290 https://doi.org/10.1158/1538-7445.am2024-869

View Full Paper

Ask AI

Bookmark

Implication

Preclinical genomic analysis reveals clone-specific DNA replication timing in breast and ovarian cancers, highlighting how copy number alterations alter subclone fitness.

Single-Cell DNA Replication Timing and Clonal Dynamics in Genomically Unstable Cancers

Key Points

Discussion

Implication

Cite This Study

Single-Cell DNA Replication Timing and Clonal Dynamics in Genomically Unstable Cancers

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider