September 5, 2024Cancer Research

Abstract B074: Clonal decomposition and DNA replication states defined by scaled single-cell DNA and RNA sequencing suggest clone-specific therapeutic vulnerabilities in neuroblastoma

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Subclonal neuroblastoma populations display distinct replication timing profiles and discordant sensitivities to targeted lorlatinib therapy across patient-derived xenografts.
Single-cell analysis of 9,410 neuroblastoma cells identified 11 polyclonal tumors with early driver mutations and copy number alterations across diverse disease stages.
Single-cell whole-genome DNA sequencing integrated with transcriptomics mapped clonal evolution; patient-derived xenograft models require further clinical confirmation.

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Implication

Single-cell genomic profiling demonstrates clone-specific replication timing and treatment responses in neuroblastoma, highlighting mechanisms driving subclonal drug resistance.

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Bhalshankar et al. (2024) studied this question.

synapsesocial.com/papers/68e5944ab6db64358752f987 https://doi.org/10.1158/1538-7445.pediatric24-b074

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Implication

Single-cell genomic profiling demonstrates clone-specific replication timing and treatment responses in neuroblastoma, highlighting mechanisms driving subclonal drug resistance.

Abstract B074: Clonal decomposition and DNA replication states defined by scaled single-cell DNA and RNA sequencing suggest clone-specific therapeutic vulnerabilities in neuroblastoma

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Discussion

Implication

Cite This Study

Abstract B074: Clonal decomposition and DNA replication states defined by scaled single-cell DNA and RNA sequencing suggest clone-specific therapeutic vulnerabilities in neuroblastoma

Key Points

Discussion

Implication

Cite This Study

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