Case report highlights whipple's disease as a differential diagnosis in blood culture-negative endocarditis, suggesting the need for thorough clinical investigation.
Whipple’s endocarditis is a rare infectious condition caused by the bacterium Tropheryma whipplei. Although its systemic form is the most widely recognized, the infection exhibits a broad spectrum of extraintestinal manifestations, with blood culture-negative infective endocarditis being the most common form of cardiac involvement. The case presented in this study underscores the importance of clinical investigation for accurate diagnosis and the application of appropriate treatment.
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Soares et al. (2025) studied this question.
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