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Observational analysis suggests Whipple disease may cause endocarditis with atypical symptoms, highlighting its importance as a diagnosis.
Whipple disease should be considered in culture-negative endocarditis, particularly with chronic arthralgias or gastrointestinal symptoms. Importantly, Twhipplei endocarditis may also occur without classic systemic features.
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López-Gutiérrez et al. (2025) studied this question.
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