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August 18, 2025AJP Endocrinology and MetabolismOpen Access

Hyperglycemia worsens gut bacterial infection through intestinal Wnt, but independent of endotoxemia or obesity

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Authors

ABArshpreet BhatwaTLTrevor C. LauJMJoseph B. McPhee

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Overview

Observational analysis reveals hyperglycemia exacerbates diarrhea severity in enteric infections, indicating a potential therapeutic target.

Key Points

  • Hyperglycemia significantly increases the severity of diarrhea during an Escherichia coli outbreak in humans, linking diabetes to worse gut infections.
  • Infection with Citrobacter rodentium showed a higher mortality in hyperglycemic mice models of type 1 and type 2 diabetes compared to those with obesity.
  • The study used metabolic endotoxemia assessments and intestinal Wnt/β-Catenin evaluation to explore interactions during infections.
  • Blocking Wnt/β-Catenin or lowering blood glucose improved outcomes, suggesting potential therapeutic strategies for hyperglycemic patients.

Cite This Study

Bhatwa et al. (2025) studied this question.

synapsesocial.com/papers/68af475aad7bf08b1ead4366https://doi.org/10.1152/ajpendo.00251.2025
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