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This is a Animal Study study (also classified as: Observational).

August 19, 2025Nutrition and DiabetesOpen Access

Kefir-derived exopolysaccharide ameliorates hyperglycemic control and beta cell integrity in a rat model of type 2 diabetes mellitus

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Administration of kefir-derived exopolysaccharides enhances insulin sensitivity in diabetic rats, indicating potential therapeutic value.

High-dose KEPS effectively stabilizes blood glucose levels and improves insulin sensitivity in diabetic rats, leading to better overall health.
In diabetic rats, KEPS treatment resulted in upregulation of GLUT2 and reduced β cell damage after 4 weeks of administration.
Assessment involved administering streptozotocin and a high-fat diet to induce type 2 diabetes in male SD rats, followed by KEPS treatment.
These findings suggest kefir-derived exopolysaccharides may represent a novel nutraceutical approach for diabetes management, calling for further human studies.

Yen et al. (2025) studied this question.

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