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November 20, 2025Molecular Nutrition & Food Research

Investigation of the Protective Effects of Synbiotic Buffalo Kefir in Rats With Type 1 Diabetes Mellitus

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Authors

İBİlkay BuranSSSeyda SecginHAH. Ceren Akal

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Implication

In vivo study reveals synbiotic buffalo kefir lowers oxidative stress markers in type 1 diabetes rats, suggesting potential protective effects.

Key Points

  • This research aims to investigate the protective effects of synbiotic buffalo kefir on markers of type 1 diabetes mellitus in rats.
  • In vivo study with 70 male rats over 28 days
  • Administration of buffalo kefir produced by specific probiotic strains and FOS
  • Physicochemical and microbiological properties analyzed
  • Blood analysis for MDA, SOD, GPX, and diabetes parameters
  • Probiotic count highest in kefir with FOS + Lactobacillus acidophilus
  • Triglycerides significantly decreased in rats consuming FOS + Bifidobacterium bifidum
  • Lipid peroxidation decreased; antioxidant enzymes SOD and GPX increased
  • MDA levels reduced in all diabetic groups consuming synbiotic kefir

Cite This Study

Buran et al. (2025) studied this question.

synapsesocial.com/papers/6924f08cc0ce034ddc3506bbhttps://doi.org/10.1002/mnfr.70324
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kefir-derived exopolysaccharide ameliorates hyperglycemic control and beta cell integrity in a rat model of type 2 diabetes mellitus2025 · 7 citations
  2. 2Transdisciplinary Tactics and Prospects for Medical and Commercial Advancement in Kefir2024
  3. 3Kefir and Its By-Products Supplementation Reduces Inflammation and Oxidative Stress, Improves Intestinal Barrier Integrity, and Modulates the Gut Microbiota in Animal Models of Inflammatory Bowel Disease: A Systematic Review2026 · 2 citations
  4. 4The Effects of Synbiotic Supplementation on Glycemic Status, Lipid Profile, and Biomarkers of Oxidative Stress in Type 1 Diabetic Patients. A Placebo-Controlled, Double-Blind, Randomized Clinical Trial2020 · 62 citations
  5. 5Study the effects of Frankincense aqueous extract with / without synbiotic on diabetic male rats2024 · 1 citations