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Demographic and immunological status of Seronegative HLAB27 patients in Central India -A prospective study

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HLA-B27 positivity was found in 15% of seronegative spondyloarthritis patients, indicating a significant relationship with demographic factors.
Real time PCR analysis confirmed HLA-B27 status and showed a higher prevalence in males versus females (62.1% vs. 37.9%).
Among juvenile cases, 41% tested positive for HLA-B27, with higher inflammatory markers noted in males.
Recommendations include HLA-B27 testing to improve diagnosis and reduce unnecessary medical consultations for patients.

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Cross-sectional study reveals demographic insights and inflammatory markers in seronegative HLA-B27 patients, suggesting diagnostic potential.

Sodani et al. (2025) studied this question.

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Cross-sectional study reveals demographic insights and inflammatory markers in seronegative HLA-B27 patients, suggesting diagnostic potential.