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May 11, 2026CureusOpen Access

Human Leucocyte Antigen (HLA) B27 Allele Positivity Rate Among Patients Suffering From Spondyloarthritis and Its Distribution According to Age and Gender: A Hospital-Based Cross-Sectional Study

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This research investigates the rate of HLA B27 allele positivity in spondyloarthritis patients and its correlation with age and gender.
Conducted a cross-sectional study with 207 clinically diagnosed/suspected spondyloarthritis cases.
Collected EDTA blood samples and applied SSP-PCR for HLA B27 allele testing.
Analyzed the association of HLA B27 positivity with age and gender.
Among 207 patients, 70 (33.8%) tested positive for HLA-B27 allele.
Positivity was significantly associated with male sex and individuals aged 15-30 years (p<0.05).
The most common form was ankylosing spondylitis, with 28 (70%) cases.

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Cross-sectional study estimates HLA B27 allele positivity in spondyloarthritis patients, suggesting early diagnostic potential.

Deka et al. (2026) studied this question.

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