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August 19, 2025

Reconstructing the Ischemic Cerebrum by Transplanted Human Neurons

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Neural transplantation improves synapse organization in ischemic mouse cortex, suggesting a new avenue for treatment.

Transplanted human cortical progenitors integrated into cortical and subcortical neural circuits, aiding recovery.
A close relationship was found between transcription profiles of a cortical neuronal subtype and circuit integration.
Neuronal tracing and RNA sequencing revealed critical insights into axon guidance and synapse assembly mechanisms.
Machine learning identified transcriptional codes related to axonal projection and circuit repair, highlighting potential therapeutic applications.

Wang et al. (2025) studied this question.

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