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October 12, 2025Stem Cell Reviews and ReportsOpen Access

Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke

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Authors

HYHiroaki YamashitaAoyama Gakuin University TKTetsuhiro KikuchiKyoto University YKYusaku KodakaKyoto University

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Implication

Transplantation of human iPSC-derived cortical neurons improves fine motor function in mice with ischemic stroke, suggesting potential for recovery-focused therapies.

Key Points

Significant improvements in fine motor function were observed after transplanting iPSC-derived neurons into stroke-affected mice.
The transplantation group showed enhanced performance in the foot fault test, indicating improved motor skills post-treatment.
Grafted neurons demonstrated neurite extension, connecting to the corticospinal tract and indicating integration into neural circuits.
Further investigations are necessary for understanding long-term safety and functional connectivity of transplanted cells.

Cite This Study

Yamashita et al. (2025) studied this question.

synapsesocial.com/papers/68ec384042a190b2c351973b https://doi.org/10.1007/s12015-025-10981-x

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Implication

Transplantation of human iPSC-derived cortical neurons improves fine motor function in mice with ischemic stroke, suggesting potential for recovery-focused therapies.

Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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