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This is a Systematic Review study (also classified as: Meta-Analysis).

August 19, 2025Diabetic MedicineOpen Access

Associations of glycaemia‐related risk factors with dementia and cognitive decline in individuals with type 2 diabetes: A systematic review and meta‐analysis

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Higher risks of all-cause dementia and Alzheimer's disease were linked to hypoglycaemia, at 49% and 31% respectively.
The maximum hazard ratios for hypoglycaemia frequency reached 2.36-2.60, indicating significant risk increases.
Meta-analysis of 40 studies highlighted a positive risk gradient for HbA1c, with maximum significant hazard ratios of 1.40-3.88.
Findings suggest a clear relationship between glycaemia factors, hypoglycaemia history, and higher dementia risk in individuals with type 2 diabetes.

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Systematic review finds hypoglycaemia and HbA1c linked to cognitive decline in type 2 diabetes, suggesting risks for dementia.

Tabesh et al. (2025) studied this question.

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