Key result
Higher HbA1c is linked to ~47% greater incident dementia risk.
Why the study?
Does higher glycemic level and longer diabetes duration increase the risk of incident dementia in older adults?
Population
5030 participants without dementia, mean age 75.4 years, 58.6% female, 21% Black, 28% with diabetes.
Comparison
Higher glycemic level and longer duration of… vs Lower glycemic level, shorter duration of…
Design
Cohort
Follow-up
median 9.0 years
Authors
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In older adults, higher glycemic levels (HbA1c ≥7%) and longer diabetes duration (≥5 years) are associated with a significantly increased risk of incident dementia.
Cohort (n=5,030)
Yes
Does higher glycemic level and longer diabetes duration increase the risk of incident dementia in older adults?
Hazard Ratio: 1.47 (95% CI 1.22–1.77)
In older adults, higher glycemic levels (HbA1c ≥7%) and longer diabetes duration (≥5 years) are associated with a significantly increased risk of incident dementia.
Smith et al. (2026) conducted a cohort in Diabetes and incident dementia (n=5,030). Higher glycemic level (HbA1c ≥7%) and longer diabetes duration (≥5 years) vs. Lower glycemic level (HbA1c <7%) and shorter duration (<5 years) was evaluated on incident dementia (HR 1.47, 95% CI 1.22-1.77). Higher glycemic levels (HbA1c ≥7%) and longer diabetes duration (≥5 years) increased incident dementia risk (HR 1.47, 95% CI 1.22-1.77 and HR 1.57, 95% CI 1.24-1.98, respectively).
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