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August 19, 2025Open Access

Human single-cell atlas analysis reveals heterogeneous endothelial signaling

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Endothelial cells exhibited significant heterogeneity influenced by tissue and vessel types, highlighting their complex biology.
Analysis of over three million single cells revealed distinct communication patterns across different tissues, particularly in heart and kidney.
Computational modeling of cell-cell communications identified unique CCC interactions tied to specific microenvironments.
Findings underscore the importance of understanding endothelial cell heterogeneity for insights into tissue regulation and function.

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Systematic analysis reveals diverse endothelial signaling patterns across tissue microenvironments, indicating specific interactions.

Zhu et al. (2025) studied this question.

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