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This research aims to explore endothelial cell heterogeneity in different human tissues and the regulation by microenvironments.

Human Single-cell Atlas Analysis Reveals Heterogeneous Endothelial Signaling

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This research aims to explore endothelial cell heterogeneity in different human tissues and the regulation by microenvironments.
Analyzed over three million single cells from single-cell RNA-seq datasets across 15 human tissues.
Developed a computational pipeline for cell–cell communication analyses.
Identified CCC patterns using topic modeling.
EC heterogeneity varies by tissue type, with cardiac and renal tissues showing tissue specificity.
Different metabolites and proteins mediate substantial variations in cell interactions across tissues.
Most CCC topics exhibited high tissue specificity, linking to microenvironmental regulation of EC functions.

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Investigations reveal diverse endothelial cell signaling in human tissues, suggesting varied microenvironmental influences.

Zhu et al. (2026) studied this question.

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