What type of study is this?

This is a In Vitro Study study (also classified as: Animal Study).

August 19, 2025VirulenceOpen Access

Combination of isobavachalcone and amphotericin B has antifungal effect against Cryptococcus neoformans and protects host tissue damage by inhibiting ferroptosis

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Combination therapy demonstrates enhanced antifungal activity and protective host response in C. elegans, suggesting new treatment avenues.

The combination of IBC and AmB reduced the MIC of AmB from 1 μg/mL to 0.25 μg/mL, showing a clear enhancement in antifungal potency.
In C. elegans, treatment with IBC-AmB lowered levels of reactive oxygen species while boosting glutathione, demonstrating protective effects against ferroptosis.
Assessment methods included in vitro and in vivo analyses, indicating the dual action of the combination on both the pathogen and host response.
This approach may reduce adverse effects of AmB and enhance therapeutic effectiveness for cryptococcal infections.

Qian et al. (2025) studied this question.

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Combination therapy demonstrates enhanced antifungal activity and protective host response in C. elegans, suggesting new treatment avenues.