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August 19, 2025Open Access

The negative acute phase response and not serum C-reactive protein is a major biomarker of major depression: a precision nomothetic psychiatry study

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Authors

MMMichael MaesEuropean Union MNMengqi NiuUniversity of Electronic Science and Technology of China XZXu ZhangAmerican College of Chest Physicians

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Implication

Case control study highlights negative acute phase response and not C-reactive protein in major depression, suggesting a new understanding of biomarkers.

Key Points

Negative acute phase response is significantly reduced in major depression patients compared to controls, emphasizing new biomarker potential.
Cases with serum hsCRP levels below 3 mg/L display significant correlations with negative acute phase proteins like albumin and transferrin.
Methodology included assessments of serum hsCRP, albumin, transferrin, and immune markers among 125 MDD patients and 40 controls.
Findings suggest a unique inflammatory profile in major depression, calling for a shift in understanding biomarkers beyond traditional measures.

Cite This Study

Maes et al. (2025) studied this question.

synapsesocial.com/papers/68af494dad7bf08b1ead4c00 https://doi.org/10.1101/2025.08.15.25333787

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Implication

Case control study highlights negative acute phase response and not C-reactive protein in major depression, suggesting a new understanding of biomarkers.

The negative acute phase response and not serum C-reactive protein is a major biomarker of major depression: a precision nomothetic psychiatry study

Discussion

Member takes

Implication

Key Points

Cite This Study

The negative acute phase response and not serum C-reactive protein is a major biomarker of major depression: a precision nomothetic psychiatry study

Discussion

Member takes

Implication

Key Points

Cite This Study

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