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August 19, 2025Journal of Clinical InvestigationOpen Access

Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy

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Authors

DTDiana Tavares‐FerreiraBSBreanna Q. ShenJMJuliet M. Mwirigi

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Overview

Transcriptomic analysis shows inflammatory activation and changes in sensory axons in diabetic peripheral neuropathy, suggesting novel therapeutic targets.

Key Points

  • Inflammatory activation is evident in peripheral nerves of patients with diabetic peripheral neuropathy, highlighting significant changes.
  • Comparing diabetic peripheral nerves reveals distinct immunological features and key pathway differences in affected axons.
  • Spatial transcriptomics indicates shifts in immune cell types alongside axonal loss progression in diabetic nerves, revealing underlying mechanisms.
  • Understanding altered mRNA transport in sensory axons may offer new insights into nerve degeneration in diabetic conditions.

Cite This Study

Tavares‐Ferreira et al. (2025) studied this question.

synapsesocial.com/papers/68af4953ad7bf08b1ead4f36https://doi.org/10.1172/jci184075
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy2024 · 3 citations
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  5. 5Integrative Transcriptomic Profiling Identifies <i>TLR9</i> as a Key Biomarker of Diabetic Peripheral Neuropathy2026