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August 1, 2026Scientific ReportsOpen Access

Small RNA sequencing of human sural nerves identifies widespread microRNA dysregulation and Schwann cell-localized miR-21-5p in advanced diabetic neuropathy

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Authors

SGSneha A. GummadiRJRyan R. JuVPVictoria Pastor

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Overview

Randomized trial profiles microRNAs in diabetic neuropathy, suggesting links to inflammation and nerve degeneration.

Key Points

  • This study aims to profile microRNAs in human sural nerves to understand their roles in diabetic peripheral neuropathy.
  • Conducted small RNA sequencing on human sural nerves with and without diabetic peripheral neuropathy.
  • Developed a computational pipeline for microRNA quantification, differential expression, and target enrichment analysis.
  • Analyzed the association of miRNAs with nerve regeneration pathways and Schwann cell activity.
  • Identified nearly 10% of microRNAs as dysregulated in DPN, with 74% significantly downregulated.
  • miR-21-5p was significantly upregulated in DPN and correlated positively with axonal loss severity.
  • Target gene enrichment analysis revealed pathways linked to inflammation, apoptosis, and nerve regeneration impairment.

Cite This Study

Gummadi et al. (2026) studied this question.

synapsesocial.com/papers/6a6d97eae258b358b3c6ac7ahttps://doi.org/10.1038/s41598-026-64136-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy2025
  2. 2<scp>MiR</scp> ‐210‐3p is upregulated in diabetic peripheral neuropathy and may be involved in the progression of the disease by targeting brain‐derived neurotrophic factor2026
  3. 3Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy2024 · 3 citations
  4. 4Emerging Roles of microRNAs as Biomarkers and Therapeutic Targets for Diabetic Neuropathy2020 · 44 citations
  5. 5Clinical Importance of miRNA in Diabetic Neuropathy: Pathophysiology, Diagnosis, and Therapeutic Potential2025 · 1 citations