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October 22, 2020Frontiers in NeurologyOpen Access

Emerging Roles of microRNAs as Biomarkers and Therapeutic Targets for Diabetic Neuropathy

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Key result

MicroRNAs play an important role in the pathogenesis of diabetic neuropathy and hold promise as both biomarkers and therapeutic targets, particularly when packaged within extracellular vesicles.

Why the study?

The exact pathophysiological mechanisms of diabetic neuropathy remain unclear, and the roles of microRNAs as biomarkers and potential therapeutic targets warrant review.

Design

Review

Authors

BFBaoyan FanMCMichael ChoppZZZheng Gang Zhang

Discussion

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Member takes

Overview

Supports microRNA research in diabetic neuropathy; leaves open clinical translation as biomarkers or therapies pending validation.

Structured PICO

P
Population
Patients with or models of diabetic neuropathy (DN)
I
Intervention
microRNAs (miRNAs) and exosomal miRNAs

This review highlights the potential of miRNAs, particularly when packaged in extracellular vesicles, as novel biomarkers and therapeutic targets for diabetic neuropathy.

Limitations

  • miRNA instability, targeting specificity, and potential toxicities
  • The biological function of the majority of miRNAs has yet to be investigated
  • The regulation of a single miRNA may not be sufficient to reverse the impairments of diabetic neuropathy
  • Most miRNA-related studies were performed in different rodent strains utilizing different methods to induce diabetic neuropathy
  • miRNA instability
  • targeting specificity
  • potential toxicities

Cite This Study

Fan et al. (2020) conducted a review in Diabetic Neuropathy. microRNAs was evaluated. MicroRNAs play an important role in the pathogenesis of diabetic neuropathy and hold promise as both biomarkers and therapeutic targets, particularly when packaged within extracellular vesicles.

synapsesocial.com/papers/6a93c9acbbbb721b13fc134dhttps://doi.org/10.3389/fneur.2020.558758
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Importance of miRNA in Diabetic Neuropathy: Pathophysiology, Diagnosis, and Therapeutic Potential2025 · 1 citations
  2. 2Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies2025 · 10 citations
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  5. 5The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy2022 · 12 citations