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September 20, 2022Journal of Pharmacy and Pharmacology

The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy

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Key result

MicroRNAs emerge as potential targets for diabetic cardiomyopathy diagnosis, prognosis, and treatment.

Why the study?

Diabetic cardiomyopathy is associated with increased morbidity and mortality in diabetic patients, and microRNAs can act as cardioprotective or cardiotoxic agents.

Do microRNAs serve as potential biomarkers and therapeutic targets for diabetic cardiomyopathy?

Design

Literature review

Authors

MRMahasin Abdel RhmanPOPeter M. O. Owira

Discussion

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Member takes

Overview

MicroRNA biomarkers should not yet change diabetic cardiomyopathy practice; leaves open their diagnostic and therapeutic utility pending prospective trials.

Structured PICO

Do microRNAs serve as potential biomarkers and therapeutic targets for diabetic cardiomyopathy?

P
Population
Diabetic cardiomyopathy (DCM)
I
Intervention
microRNAs (miRNAs) targeted therapies (miRNA mimics and anti-miRNAs)
O
Outcome
Role of miRNAs in pathophysiology, diagnosis, and treatment of DCM

MicroRNAs are promising biomarkers and therapeutic targets for managing diabetic cardiomyopathy.

Cite This Study

Rhman et al. (2022) conducted a review in Diabetic cardiomyopathy. microRNAs was evaluated. MicroRNAs serve as attractive potential targets for diabetic cardiomyopathy diagnosis, prognosis, and treatment due to their distinctive expression profile in disease development.

synapsesocial.com/papers/6a14b4904084ab02a46bf4aehttps://doi.org/10.1093/jpp/rgac066
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-invasive Diagnostic Imaging Techniques as a Window into the Diabetic Heart: A Review of Experimental and Clinical Data2007 · 15 citations
  2. 2Early detection of diabetic cardiomyopathy: usefulness of tissue Doppler imaging2005 · 135 citations
  3. 3Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways2016 · 115 citations
  4. 42016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure2016 · 5,932 citations
  5. 5miRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart2015 · 226 citations