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February 5, 2026Journal of Diabetes InvestigationOpen Access

MiR ‐210‐3p is upregulated in diabetic peripheral neuropathy and may be involved in the progression of the disease by targeting brain‐derived neurotrophic factor

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Authors

YZYafei ZhaoLWLiu WangDFDongcai Feng

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Overview

Investigates miR-210-3p as a biomarker in diabetic peripheral neuropathy, suggesting its role in disease mechanisms.

Key Points

  • The research aims to establish miR-210-3p as a diagnostic biomarker for diabetic peripheral neuropathy (DPN) and investigate its molecular impact in the disease process.
  • Measured serum miR-210-3p expression using RT-qPCR in patients and controls.
  • Evaluated diagnostic performance via ROC curve analysis.
  • Conducted multivariate logistic regression to identify risk factors for DPN.
  • Established an RSC96 Schwann cell model under high-glucose conditions for functional testing of miR-210-3p.
  • Performed dual-luciferase reporter experiments to confirm targeting of BDNF.
  • Serum miR-210-3p levels were significantly higher in DPN patients (P < 0.001).
  • Achieved an AUC of 0.830 for miR-210-3p, indicating good diagnostic performance.
  • Identified miR-210-3p, fasting blood glucose, and glycated hemoglobin A1c as independent risk factors for DPN.
  • MiR-210-3p negatively regulated BDNF, impacting Schwann cell functions.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/698433c8f1d9ada3c1fb1375https://doi.org/10.1111/jdi.70199
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Also Consider

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  1. 1Diagnostic value and bioinformatics-based mechanistic exploration of serum miR-7977 in diabetic peripheral neuropathy2025
  2. 2Identification of Blood miR-216a, miR-377 and Their Target Genes ANGPTL4, GAP-43 and Serum of PPARG as Biomarkers for Diabetic Peripheral Neuropathy of Type 2 Diabetes2021 · 13 citations
  3. 3Small RNA sequencing of human sural nerves identifies widespread microRNA dysregulation and Schwann cell-localized miR-21-5p in advanced diabetic neuropathy2026
  4. 4<scp>miR</scp> ‐27a‐3p Upregulation and Netrin‐1 Deficiency Drive Inflammatory Responses and Nerve Degeneration in Patients With Diabetes2025
  5. 5Correlation Study of Peripheral Blood miR-155 and miR-146a Expression Levels with Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes2024