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September 10, 2025Turkish Journal of BiochemistryOpen Access

Diagnostic value and bioinformatics-based mechanistic exploration of serum miR-7977 in diabetic peripheral neuropathy

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Authors

ZLZhiquan LinLLLi Liu

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Overview

Observational analysis revealed miR-7977's diagnostic potential in type 2 diabetes patients, indicating a link to diabetic peripheral neuropathy.

Key Points

  • Serum miR-7977 levels were significantly higher in T2DM patients, with further increases in those with DPN.
  • Elevated miR-7977 levels correlate positively with malondialdehyde and negatively with antioxidant markers in patients.
  • MDM2 was identified as a target gene of miR-7977, displaying opposite expression trends in DPN patients.
  • Serum MDM2 combined with miR-7977 can effectively diagnose T2DM in patients with diabetic peripheral neuropathy.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68c1a11f54b1d3bfb60dbaa7https://doi.org/10.1515/tjb-2024-0279
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