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August 19, 2025Journal of BiophotonicsOpen Access

Comparative Analysis of Reflectance Confocal Microscopy and Multiphoton Microscopy in Basal Cell Carcinoma Diagnosis

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RCM revealed superior visualization of tumor nests and vascular patterns in BCC lesions, enhancing diagnosis.
Preoperative imaging with RCM showed significant architectural differences in collagen metrics, p < 0.01.
Dermoscopy and in vivo RCM were combined with MPM imaging for comprehensive diagnostic evaluation.
Joint use of RCM and MPM may enable improved risk stratification and assessment for BCC patients.

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Analysis shows RCM enhances tumor visualization while MPM aids in collagen assessment, improving BCC diagnosis.

Zhong et al. (2025) studied this question.

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