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September 10, 2025Clinical and Experimental Dermatology

Reflectance Confocal Microscopy for Monitoring Treatment Response in Superficial Basal Cell Carcinoma: Diagnostic Challenges Due to Scar Formation

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Authors

MCMarie ClarkHenry Ford Health SystemJWJohn WuennenbergHenry Ford Health SystemJMJalal MaghfourHenry Ford Health System

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Overview

Prospective analysis of RCM features in superficial basal cell carcinoma patients after treatment, indicating diagnostic challenges.

Key Points

  • Statistically significant changes in RCM features were found after treatment in superficial basal cell carcinoma patients, indicating treatment response.
  • Notable RCM features included tumor islands with hyperreflective aggregates and peripheral palisading, highlighting diagnostic sensitivity.
  • RCM imaging was utilized across ten subjects, combining clinical examination and histology for in-depth analysis of treatment effects.
  • Findings suggest caution in interpreting nuclear streaming and fibrosis during RCM imaging in basal cell carcinoma cases.

Cite This Study

Clark et al. (2025) studied this question.

synapsesocial.com/papers/68c1955c9b7b07f3a06192c2https://doi.org/10.1093/ced/llaf407
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reflectance Confocal Microscopy for Treatment Response Monitoring in Locally Advanced Basal Cell Carcinoma Treated with Sonidegib: A Prospective Observational Study2026
  2. 2The use of Reflectance Confocal Microscopy to diagnose Basal Cell Carcinoma in the United Kingdom: A Prospective Observational Trial at a Single Centre2024 · 5 citations
  3. 3Comparative Analysis of Reflectance Confocal Microscopy and Multiphoton Microscopy in Basal Cell Carcinoma Diagnosis2025
  4. 4Improving Basal Cell Carcinoma Subtype Diagnosis with Dermoscopy and Reflectance Confocal Microscopy: A Multicenter Prospective Study2026 · 3 citations
  5. 5P056 Reflectance confocal microscopy and basal cell carcinoma: is it time to embrace the new technology?2024