Retrospective analysis shows altered amino acid and acylcarnitine levels in newborns from mothers with hypertensive disorders, suggesting impacts on neonatal metabolism.
Key Points
Altered levels of nine amino acids and varying acylcarnitines were found in neonates from mothers with hypertensive disorders in pregnancy.
Among the amino acids, those involved in arginine and proline metabolism and the urea cycle showed significant differences.
This retrospective case-control study included 1,228 women with hypertensive disorders and matched controls, focusing on newborn screening results.
These findings highlight the potential metabolic impacts of maternal hypertensive conditions on neonatal health outcomes.