SuFEx Reactions When Shaken Not Stirred

Click reactions display many of the goals desired for more sustainable chemical conversions. Yet, the solvent used is an often overlooked aspect in determining the environmental impact of reactions. In the current paper, the first mechanochemical method is developed for the efficient and solvent‐free SuFEx reaction of sulfonyl fluorides with a wide range of phenols. After outlining the optimization process, which yields an easy‐to‐use and robust method. The broad scope of this approach is evidenced, and demonstrate this potential via the application to a range of natural phenols that also display other functionalities, and several gram‐scale syntheses.