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NMR‐Based Clinical Metabolomics Reveals Distinctive Metabolic Signatures in Systemic Sclerosis and Systemic Lupus Erythematosus

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Significant metabolic distinctions help differentiate systemic sclerosis and lupus, supporting potential diagnostic tools.
SLE characterized by disrupted glycolysis and mitochondrial dysfunction, while SSc shows unique amino acid metabolism alterations.
Analysis of serum metabolites employed NMR spectroscopy and statistical measures to evaluate differences across patient groups.
Findings emphasize metabolic heterogeneity in autoimmune diseases, highlighting the need for personalized therapeutic strategies.

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Metabolomics reveals key biomarkers distinguishing systemic sclerosis and lupus, suggesting diverse metabolic pathways.

Singh et al. (2025) studied this question.

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