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This research aims to understand immune cell composition and metabolic changes in systemic lupus erythematosus and psoriatic arthritis.

Phenotypic and Metabolic Signatures in Chronic Autoimmune Inflammation 2308477

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This research aims to understand immune cell composition and metabolic changes in systemic lupus erythematosus and psoriatic arthritis.
Combined spectral flow cytometry and CITE-Seq to profile immune cells and metabolic pathways.
Analyzed peripheral white blood cells from SLE patients, psoriatic arthritis patients, and healthy donors.
Used high-dimensional computational analysis to identify immunophenotypic and metabolic differences.
Significant immunophenotypic changes were observed across 44 immune cell populations in both SLE and PsA.
In SLE, T cells showed strong dependence on OXPHOS with altered frequencies and activity in developmental subsets.
PsA patients demonstrated increased NKT-cell frequencies, suggesting involvement of lipid antigens.

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Randomized trial investigates metabolic changes and immune cell profiles in SLE and PsA, suggesting potential biomarkers for treatment.

Aliraj et al. (2026) studied this question.

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