August 14, 2025Open Access

A population-scale atlas of blood and tissue in lupus nephritis

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Authors

SGSiddarth GurajalaBrigham and Women's Hospital NSNicholas SugiartoMRC Centre for Reproductive Health MCMichelle CurtisBroad Institute

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Implication

This analysis reveals distinct immune cell states in lupus nephritis patients, suggesting targeted immunotherapies may be effective for disease management.

Key Points

Lupus nephritis is linked to distinct immune and tissue cell states, correlating with disease chronicity.
Analysis of 538K single-cell profiles from kidney biopsies identified specific macrophage populations associated with activity in the disease.
The study utilized kidney biopsies and blood samples, integrating data to define pathological features and their association with chronicity.
Identifying tissue-specific immune populations may enable new therapeutic strategies for managing lupus nephritis.

Cite This Study

Gurajala et al. (2025) studied this question.

synapsesocial.com/papers/68af4965ad7bf08b1ead5cea https://doi.org/10.1101/2025.08.11.669754

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Implication

This analysis reveals distinct immune cell states in lupus nephritis patients, suggesting targeted immunotherapies may be effective for disease management.

A population-scale atlas of blood and tissue in lupus nephritis

Discussion

Member takes

Implication

Key Points

Cite This Study

A population-scale atlas of blood and tissue in lupus nephritis

Discussion

Member takes

Implication

Key Points

Cite This Study

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